Trending lipedema treatment research highlights the awareness of Lipoedema as a connective tissue disorder and the pathophysiology of fibrosis formation and inflammation. The use of negative pressure for soft tissue mobilisation, disruption of adipocyte formation, and lymphatic reabsorption is recognised as an integral part of the comprehensive management of this condition. Vibration in combination with negative pressure can be an added benefit for both pain modulation and lymph reabsorption. Healthcare professionals will learn aspects for the application of negative pressure and vibration within the treatment using video demonstrations and patient experience.